What is Xeljanz?
Xeljanz and Xeljanz XR are the brand names for the oral systemic treatment tofacitinib. Different oral systemic treatments work in different ways to reduce symptoms of psoriatic disease. Newer oral systemic treatments, such as Xeljanz, work similarly to biologics by targeting specific parts of the immune system to reduce symptoms and inflammation.
How Does Xeljanz Work?
Xeljanz targets a specific part of the immune system (Janus kinase) to reduce the overactive response associated with psoriatic disease. The oral treatment also aids in reducing joint tenderness and swelling.
How Is Xeljanz Used?
Xeljanz is taken by mouth twice daily as a pill. Xeljanz XR is an extended release formula of the same treatment and is taken by mouth once daily as a pill.
What Are the Risks?
Xeljanz/Xeljanz XR may raise your risk for:
- High lipid levels
- High liver enzymes
- Low blood count
- Lymphoma and other malignancies
- Gastrointestinal perforations
Common Side Effects
In clinical trials, the most common side effects were headaches, diarrhea, and upper respiratory infections.
