Rinvoq (upadacitinib)

Rinvoq works by targeting a specific part of the immune system (Janus Kinase) to reduce the overactive response associated with psoriatic arthritis.

What is Rinvoq?

What is Rinvoq?

Rinvoq is the brand name for the oral systemic treatment upadacitinib. Different oral systemic treatments work in different ways to reduce symptoms of psoriatic disease. Newer oral systemic treatments, such as Rinvoq, work similarly to biologics by targeting specific parts of the immune system to reduce symptoms and inflammation.

How Is It Used?

Rinvoq is a pill (15mg) that is taken once per day.

People Who Can Take Rinvoq

The U.S. Food and Drug Administration (FDA) approved Rinvoq to treat adults living with psoriatic arthritis in 2021. Rinvoq is also approved to treat conditions other than psoriatic arthritis including rheumatoid arthritis.

What Are the Risks?

Rinvoq may increase your chance of:

  • Serious infections
  • Cancer
  • Major cardiovascular events such as heart attack or stroke
  • Blood clots
  • Tears in the stomach or intestines

Common Side Effects

In clinical trials, the most common side effects were upper respiratory infections, nausea, cough, fever, and acne.

Using Rinvoq With Other Treatments

Rinvoq may not be safe to use with certain prescriptions including JAK inhibitors, biologic DMARDs, or with potent immunosuppressants such as azathioprine and cyclosporine, or certain over-the-counter (OTC) medications. Talk to your health care provider about whether using any other treatments with Rinvoq is right for you.

Rinvoq Fact Sheet

Learn about Rinvoq for psoriatic arthritis.

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New Treatment for PsA

The U.S. FDA approves upadacitinib for the treatment of adults with active psoriatic arthritis.

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Systemic Treatments

Learn more about types of oral systemic, biologic, and biosimilar treatments including their risks and side effects.

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Last updated on 3/25/25 by the National Psoriasis Foundation.

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