The Psoriasis Action Network (PAN) is a constituent community dedicated to ensuring a cure to psoriasis and psoriatic arthritis and improving access to treatments available today. We work to change conditions and policies that are barriers to this mission.




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Ask your members of Congress to support PPARCCA

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Ask your members of Congress to support PPARCCA

Write a letter to your members of Congress. Download our easy-to-use template. Learn more >>>

Ask your members of Congress to support PPARCCA

Write a letter to your members of Congress. Download our easy-to-use template. Learn more >>>


REACH OUT
Ask your members of Congress to support PPARCCA

Write a letter to your members of Congress. Download our easy-to-use template. Learn more >>>

Ask your members of Congress to support PPARCCA

Write a letter to your members of Congress. Download our easy-to-use template. Learn more >>>

Ask your members of Congress to support PPARCCA

Write a letter to your members of Congress. Download our easy-to-use template. Learn more >>>


VISIT
Ask your members of Congress to support PPARCCA

Write a letter to your members of Congress. Download our easy-to-use template. Learn more >>>

Ask your members of Congress to support PPARCCA

Write a letter to your members of Congress. Download our easy-to-use template. Learn more >>>

Ask your members of Congress to support PPARCCA

Write a letter to your members of Congress. Download our easy-to-use template. Learn more >>>

Ask your members of Congress to support PPARCCA

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Cure psoriasis and psoriatic arthritis
What is known about psoriasis
Research initiatives
Victor Henschel biobank
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PPARCCA 2009
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Research initiatives

Drugs in development: drug pipeline

The new drug Stelara (generic: ustekinumab) was approved by the US Food & Drug Administration for the treatment of moderate to severe psoriasis in adults on September 25, 2009. Read more >>>



The research pipeline identifies drugs currently being tested for psoriasis and/or psoriatic arthritis. The information in this pipeline chart comes from public sources and is as comprehensive as we understand it at the time of update.

The pipeline includes drugs that are in progress through phase II and phase III of clinical trials. The pipeline lists the name of the drug, the drug company, how it is administered, its mechanism of action (or how it works), the phase of study, and the indication (psoriasis or psoriatic arthritis).

Sometimes drugs have two names—the name that is used in the trial and then the brand name for when it is approved. Often the name in the trial is a combination of letters and numbers to indicate the compound's name during development at the drug company.


TOPICALS are applied to the skin, available either as prescription or over the counter. They are most commonly used to treat mild psoriasis.

Topical treatments in the pipeline
NameMechanismCompanyIndicationPhase
Taclonex-Scalp Topical Suspensionvitamin D derivative and betamethasone (glucocorticoid) combinationLEO Pharma/Warner Chilcottscalp psoriasisFDA-approved
Vectical (calcitriol) vitamin D Galderma psoriasis FDA-approved
NYC 0462 unknown Nycomed psoriasis III
LEO80190 vitamin D and hydrocortisone (glucocorticoid) LEO Pharma psoriasis III
Vectical (calcitriol) vitamin D Galderma adolescent (12-17 yrs) psoriasis II
Taclonex vitamin D derivative and betamethasone (glucocorticoid) combination LEO Pharma adolescent (12-17 yrs) psoriasis II
AS101 cytokine blocker—protease inhibitor BioMAS Ltd. psoriasis II
roflumilast cytokine blocker—phosphodiesterase inhibitor Nycomed psoriasis II
INCB18424 cytokine blocker—Jak 1-2 inhibitor Incyte corporation psoriasis II
AN2728 cytokine blocker—phosphodiesterase inhibitor Anacor Pharmaceuticals Inc. psoriasis II
CD 2027 vitamin D derivative Galderma psoriasis II
COL-121 vitamin D derivative Galderma (CollaGenex Pharmaceuticals) psoriasis II
Asord (becolcolcidiol) vitamin D derivative QuatRx Pharmaceuticals/Galderma psoriasis II
IP10.C8 immune regulator—T-cell selective peptidase inhibitor Immune Technologies & Medicine GmbH psoriasis II
LEO 29102 unknown LEO Pharma psoriasis II
LEO 19123 vitamin D derivative LEO Pharma psoriasis II
E-6201 immune regulator—MEK1 inhibitor Eisai psoriasis II


Oral treatments in the pipeline
NameMechanismCompanyIndicationPhase
Voclosporin (ISA247) cytokine blocker—calcineurin inhibitor Isotecknika psoriasis III
apremilast (CC10004)cytokine blocker—phosphodiesterase inhibitor LEO Pharma psoriasis and psoriatic arthritis II
CP690, 550cytokine blocker—Jak3 kinase inhibitor Pfizer psoriasis II
CF101immune regulator —adenosine A3 receptor agonist Can-Fite BioPharma psoriasis II
Doxercalciferol vitamin D derivative Genzyme psoriasis II
BMS-582949 cytokine blocker—p38 kinase inhibitor Bristol-Myers Squibb psoriasis II
R3421
(BCX-4208)
immune regulator —purine nucleoside phosphorylase inhibitor Roche/BioCryst psoriasis II
AEB071immune regulator —protein kinase C inhibitor Novartis psoriasis II
CH-1504 immune regulator—dihydrofolate reductase inhibitor Chelsea Therapeutics psoriasis II
M518101 cytokine blocker—phosphodiesterase inhibitor Maruho Co. Let. (Japan) psoriasis II
Act-128800 immune regulator—S1P1 receptor agonist Actelion Pharmaceuticals Ltd./Roche psoriasis II

INJECTABLES are either subcutaneous, given just under the skin, or intravenous, given into the vein. Both are most commonly used to treat moderate to severe psoriasis.

Injectable treatments in the pipeline
NameMechanismCompanyIndicationPhase
Simponi (golimumab) TNF blocker Centocor Ortho Biotech, Inc. psoriatic arthritis FDA-approved
Stelara (ustekinumab)cytokineinterleukin-12/-23 inhibitor Centocor Ortho Biotech, Inc. psoriasis Approved in Europe and Canada, pending FDA-approval
Enbrel (etanercept) TNF blocker Amgen pediatric (>4 yrs) psoriasis FDA-approval pending
ABT874 interleukin-12/-23 inhibitor Abbott psoriasis III
Stelara (ustekinumab) interleukin-12/-23 inhibitor Centocor Ortho Biotech, Inc. psoriatic arthritis II
Amevive (alefacept) T-cell inhibitor Astellas Pharma Inc. adolescent (12-17 yrs) psoriasis II
Bimosiamoseimmune regulator—selectin antagonist Revotar Biopharmaceuticals, AG psoriasis II
Cimzia (certolizumab pegol) TNF blocker UCB psoriasis II
ART-621
(PN-0621)
TNF blocker Arana Therapeutics psoriasis II
BT-061 immune regulator—helper cell blocker Biotest psoriasis II

Updated August 2009




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