Moderate to severe psoriasis: systemic medications - Soriatane (acitretin)

Acitretin is an oral retinoid, which is a synthetic form of vitamin A. Soriatane is the only oral retinoid approved by the FDA specifically for treating psoriasis.

The exact way acitretin works to control psoriasis is unknown. In general, retinoids help control the multiplication of cells including the speed at which skin cells grow and shed.

Do not take Soriatane if:

• You are pregnant, planning to become pregnant, or breastfeeding:
• You have severe liver or kidney disease:
• You have high triglycerides;
• You are allergic to retinoids.

Soriatane causes serious birth defects. Because of this risk, women of childbearing potential must have two negative pregnancy tests before starting acitretin. They must use two effective forms of birth control at least one month before beginning treatment, while on the drug and for three years after stopping treatment. Progestin-only birth control pills may not work while taking Soriatane, so women should avoid using them as a primary form of birth control.

Individuals should not donate blood during treatment and for three years after stopping treatment. Donated blood could expose pregnant women to acitretin.